INFeD® improved the hemoglobin response to erythropoietic therapy in have been reported after administration of iron dextran injection, the drug should be. iron dextran – Drug Summary. Jump to INFeD Intramuscular Inj Sol: 1mL, 50mg . INFeD: INFeD is administered by intramuscular or intravenous injection. Allergan, Inc.: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom.
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The chelate is excreted in the urine and in the feces via bile. Ankylosing spondylitis, asthma, atopy, rheumatoid arthritis, systemic lupus erythematosus SLE. Packags anaphylactoid reactions have occurred during the parenteral administration of iron dextran.
If test dose uneventful, doses of 1. Specific guidelines for dosage adjustments in hepatic impairment are not available.
Such blood losses may occur periodically in patients with hemorrhagic diatheses familial telangiectasia; hemophilia; gastrointestinal bleeding and on a repetitive basis from procedures such as renal hemodialysis. The extent of risk for anaphylactoid reactions to any specific iron dextran product is unknown and may vary among products.
A test dose of 25 mg infused over 5 minutes should be given. Serious anaphylactoid reactions require appropriate resuscitative measures. Patients receiving exogenous iron therapy require periodic monitoring of hematologic and hematinic parameters i. The table and formula described under I. Subcutaneous injection results in slow absorption and staining of subcutaneous tissue.
Iron dextran (INFeD) | – A Hematology Oncology Wiki
The formula shown below infde based on the approximation that 1 mL of normocytic, normochromic red cells contains 1 mg of elemental iron:. Evaluate transferrin saturation and serum ferritin before and during epoetin alfa treatment.
Once the infusion is completed, flush vein with NS injection. Disclaimer The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Observe patient for at least 1 hour after test dose administration. The following are generally accepted limits in the treatment of infsd patients.
Iron dextran (INFeD)
Inadequate iron stores will interfere with the therapeutic response to these agents e. Reports in the literature from countries outside the United States in particular, New Zealand have suggested that the use of intramuscular iron dextran in neonates has been associated with an increased incidence of gram-negative sepsis, primarily due to E.
Anemia, hemochromatosis, hemoglobinopathy, hemosiderosis. The stability of iron dextran in TPN solutions has not been well established.
The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Safety and efficacy have not been established. Iron dextran injection contains 50 mg of elemental iron per mL.
Achieving and maintaining adequate iron stores are essential to attaining an optimal response to MPG-epoetin beta. Serum iron, hemoglobin and hematocrit should be evaluated prior to iron therapy and apckage regular intervals during therapy.
The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows:. If test dose uneventful, infuse the remainder apckage the total calculated dose IV over 2 to 6 hours. Both animal and human data indicate that the bulk of intravenous iron is sequestered in the reticuloendothelial system i.
Reactions are usually evident within a few minutes of administration; however, observe patients for at least 1 hour after the administration of the test dose before administering the remainder of the therapeutic dose. INFeD should be injected only into the muscle mass of the upper outer quadrant of the buttock — never into the arm or other exposed areas — and should be injected nifed, with a 2-inch or 3-inch 19 or 20 gauge needle.
Major Deferasirox chelates iron and is indicated as a treatment of iron toxicity or overdose. Intermittent hemodialysis Before supplementing pzckage patients with iron dextran, a diagnosis of absolute or functional iron deficiency should be made.
U.S. Prescribing Information Disclaimer
Inject deeply into the upper outer quadrant of the buttock gluteus maximus only using a 2- or 3-inch, or gauge needle. Iron dextran should only be used in patients with a clear and confirmed need for parenteral iron therapy.
Slow intermittent intravenous IV injection: Furthermore, concomitant use of angiotensin-converting enzyme inhibitors may increase the risk for serious reactions to iron dextran. Subcutaneous injection of iron dextran results in slow absorption and staining of subcutaneous tissue. Isert the patient inffed at least 1 hour after test dose administration. If supine, the patients should be in a lateral position and the injection should be into the upper-most part of the buttock.
INFeD should not normally be given in the first four months of life. Most patients with chronic kidney disease will require supplemental iron e. inseet
Adults, Adolescents, Children, and Infants 4 months and older. The table and accompanying formula are applicable for dosage determinations only in patients with iron deficiency anemia; they are not to be used for dosage determinations in patients requiring iron replacement for blood loss.
There are limits to the volume of iron dextran that may be injected IV undiluted per 24 hours based on patient age and weight; see dosage guidelines.