Sign of Leser-Trélat. Authoritative facts about the skin from DermNet New Zealand. Leser-Trélat sign is a rare skin condition characterized by the sudden appearance of seborrheic keratoses that rapidly increase in number and size within weeks. Images in Clinical Medicine from The New England Journal of Medicine — The Sign of Leser–Trélat.

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The sign of Leser-Trelat in a case of adenocarcinoma of the lung. The primary aim of treatment is to treat the underlying cancer. Ueber ein die Krebskrankheit beim Menschen haufig begleitendes, noch wenig gekanntes Symptom.

Sign of Leser-Trélat

A possible role of a cutaneous marker for internal malignancy. Any of these distinct variations may also become irritated or inflamed, displaying either squamous eddy formation spindled cells or lymphocyte infiltration, respectively. Leser Trelat Sign – StatPearls. A case of hepatocellular carcinoma with the sign of Leser-Trelat: Retrieved from ” https: Privacy Policy Terms of Use.


Malignant Neoplasms and the Leser-Trélat Sign

Epub May N Engl J Med ; CA Cancer J Clin ; None, Conflict of Interest: J Am Acad Dermatol ; PMC ] [ PubMed: Beitrage zur Fruhdiagnose des Darmcarcinomas Hereditatsverhaltnisse und Hautveranderungen. StatPearls Publishing; Jan. Multiple eruptive seborrheic keratoses on the a face and neck, b breast, and c back Click here to view. Published by Wolters Kluwer – Medknow.

It may xign be due to the same unknown factors that induce malignant acanthosis nigricans. However, the sudden eruption of seborrhoeic keratoses in young patients points to a paraneoplastic process and should prompt an investigation for a hidden cancer. If you have any concerns with your skin or its treatment, see a dermatologist for advice. Views Read Edit View history. Narala S, Cohen PR.

As yrelat mentioned, seborrheic keratoses are a nearly ubiquitous, benign skin lesion in patients greater than 40 years of age. Create a free personal account to download free article PDFs, sign up for alerts, and more.

Because seborrhoeic keratoses and cancer are both statistically more common in elderly people it is difficult to ascertain whether the keratoses is due to the cancer ie: On physical examination, multiple, 2- to 6-mm, seborrheic keratoses and numerous pigmented filariform papillomas were present on the neck and malar regions Figure. Patients will often complain of pruritus associated with these lesions. Indian J Dermatol Venereol Leprol.


The sign of Leser-Trelat is considered to be a fairly rare paraneoplastic cutaneous marker of internal malignancy with the hallmark finding being an abrupt eruption of multiple seborrheic keratoses. Leser-Trelat sign with primary hepatic carcinoma.

Malignant Neoplasms and the Leser-Trélat Sign | JAMA Dermatology | JAMA Network

Our website uses cookies to enhance your experience. Sigm is likely that various cytokines and other growth factors produced by the neoplasm are responsible for the abrupt appearance of the seborrheic keratoses.

Click on image for details. In addition, symptomatic lesions may be destroyed with various physical methods including cryotherapy, curettage, shave removal, and electrodesiccation.