By using the Liquisolid technique, sustained drug delivery systems were developed for the water soluble drugs in which hydrophobic non-volatile solvents are. Abstract. Liquisolid technique is also known as powder solution technology. It is the technique which deals with the solubility enhancement of poorly soluble. Acta Pharm. Mar;57(1) Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical.
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In vivo evaluation of hydrochlorothiazide liquisolid tablets in beagle dogs. It should not be highly viscous organic solvent system. Mainly liquisolid technique is used for drug candidates comes under class II and class IV drugs. Viability of industrial production. A Novel Approach for Solubility Enhancement.
Bio-Pharmaceutical classification class II water insoluble drugsthe rate of oral absorption is often controlled by the rate in the GIT. These are generally prepared by solvent or co precipitation method whereby both the guest solute and carrier solvent are dissolved in common volatile solvent system such as alcohol.
In other words, tablets should be sufficiently hard to resist breaking during normal handling and yet quickly disintegrate properly after swallowing. The technique also sustained the drug release properties of the water soluble drugs by using suitable biodegradable polymers with appropriate excipient ratios.
D is the diffusion coefficient of the drug molecules transported through it, S is the surface area of the drug available for dissolution, C is the drug concentration in the bulk of the dissolving medium, Cs is the saturation solution of the drug in the dissolution medium.
These samples are then analyzed by using infra red spectrophotometer or differential scanning Calorimetry.
Pharmaceutical applications of liquisolid technique
In a study by Yousef Javadzadeh et al. Liquisolid tablets demonstrated significantly faster drug dissolution patterns in small volumes of dissolution media such as mL and mL Studies by Javadzadeh Y.
An investigation of physicochemical properties of piroxicam liquisolid compacts. Mainly superdisintegrants increases rate of drug release, its wettability and increases solubility of drug particles within short period of time.
Can be used in controlled drug delivery. Adsorption is the phenomenon in which liquid is not truly absorbed and instead of being dispersed through out the interior of the solid, the molecules only cling to its available surface, internal and external. Scanning electron microscopy shows that there is presence or absence of crystal form of the drug or excipients in the formulation. Authors who publish with this journal agree to the following terms: Coating material should be with high adsorptive property so that when used for coating the carrier particles can absorb the excessive non volatile solvent layer over the carrier particles and can give dry solid appearance to the saturated carrier particles having liquid external layer of non volatile solvent.
In this step suitable carrier material with other excipients are added into initial mixture of drug and non volatile solvent. Once drug particles solubilised in SCFs, they may be greatly recrystallised at greatly reduced particle sizes. In this study samples are taken after each specific interval of the time. Dissolution tests for liquisolid tablets were done at constant rotational speed and in identical dissolution media, thus allowing estimation of the thickness of the stagnant diffusion layer h.
Dissolution rate D R is explained according to the “Noyes – Whitney” equation and “diffusion layer model” dissolution theories.
The absorption characteristics of Hydroclorothiazide liquisolid compacts in comparison with commercial tablets were studied in beagle dogs. At near critical temperature, SCFs are highly compressible allowing moderate changes in pressure to greatly alter the density and mass transport characteristics of a fluid that determines its solvent power.
The porous material having high adsorptive properties gives desirable flow characteristics to the liquisolid system. Some investigators have used a similar approach to increase release profiles of several water-insoluble drugs Spireas, Liquisolid technque has been classified on the basis of liquid active liquisolis, viz.
Journal of Drug Delivery and Therapeutics3 4 The powder was allowed to flow through the funnel freely into the surface. Thus by altering liquisoild variables, liquisolid technique can be used for enhancing or retarding the drug release.
Pharmaceutical applications of liquisolid technique
This method is efficient, economic, viable for industrial production, also useful in control drug delivery system. Alkali metal salts of acidic drugs like penicillin and strong acid salts of basic drugs like atropine are more water soluble than parent drugs.
The concept behind this approach is adsorption and absorption both.
The Liquisolid technique: an overview
A saturated solution of the drug in dissolution media is prepared and a drop of this solution is put tecnique the surface of tablet. In this study, different formulations of liquisolid tablets using different co-solvents non-volatile solvents were prepared and the effect of aging on the dissolution behaviour of indomethacin liquisolid compacts was investigated.
It is calculated by the following formula.